By Institute of Medicine, Board on Health Promotion and Disease Prevention, Immunization Safety Review Committee
This 8th and ultimate record of the Immunization security evaluate Committee examines the speculation that vaccines, particularly the measles-mumps-rubella (MMR) vaccine and thimerosal-containing vaccines, are causally linked to autism. The committee reviewed the extant released and unpublished epidemiological stories concerning causality and reports of power biologic mechanisms through which those immunizations may possibly reason autism. Immunization defense overview: Vaccines and Autism reveals that the physique of epidemiological proof favors rejection of a causal dating among thimerosal-containing vaccines and autism. The ebook additional unearths that strength organic mechanisms for vaccine-induced autism which were generated up to now are just theoretical. It recommends a public well-being reaction that absolutely helps an array of vaccine safeguard actions and recommends that on hand investment for autism learn be channeled to the main promising parts. The booklet makes extra concepts concerning surveillance and epidemiological study, medical reports, and conversation regarding those vaccine defense concerns.
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Additional resources for Immunization Safety Review: Vaccines and Autism
2. Experimental. A mechanism can be shown to operate in in vitro systems, animals, or humans. But experimental evidence often describes mechanisms that represent only a portion of the pathological process required for expression of disease. Showing that multiple portions of a process operate in reasonable experimental models strengthens the case that the mechanisms could possibly result in disease in humans, but it cannot establish proof. Some experimental evidence is derived under highly contrived conditions.
IOM (Institute of Medicine). 1991. Adverse Events Following Pertussis and Rubella Vaccines. Washington, DC: National Academy Press. IOM. 1994. Adverse Events Associated with Childhood Vaccines: Evidence Bearing on Causality. Washington, DC: National Academy Press. IOM. 2001a. Immunization Safety Review: Measles-Mumps-Rubella Vaccine and Autism. Washington, DC: National Academy Press. IOM. 2001b. Immunization Safety Review: Thimerosal-Containing Vaccines and Neurodevelopmental Disorders. Washington, DC: National Academy Press.
However, in the absence of other evidence pointing to a causal relationship, use of the term biological plausibility, as ingrained in the language of causal inference, seems to add confusion. Thus the committee concluded in its third report (IOM, 2002b) that for future reports, the lack of clarity in the phrase “biological plausibility” warranted the adoption of new terminology and a new approach to its discussion of biological data. The committee decided to review evidence regarding “biological mechanisms” that might be consistent with the proposed relationship between a vaccine exposure and given adverse events.
Immunization Safety Review: Vaccines and Autism by Institute of Medicine, Board on Health Promotion and Disease Prevention, Immunization Safety Review Committee